What causes mitral valve regurgitation?
The mitral valve is composed of the valve leaflets, the mitral valve annulus (which forms a ring around the valve leaflets), the papillary muscles (which tether the valve leaflets to the left ventricle, preventing them from prolapsing into the left atrium), and the chordae tendineae (which connect the valve leaflets to the papillary muscles). A dysfunction of any of these portions
of the mitral valve apparatus can cause mitral regurgitation.
Heart valves open like a trapdoor. The leaflets of the mitral valve open when the left atrium contracts, forcing blood through the leaflets and into the left ventricle. When the left atrium relaxes between heart contractions, the flaps shut to prevent blood that has just passed into the left ventricle from flowing backward, in the wrong direction. When working properly, heart valves open and close fully. In mitral regurgitation, the mitral valve doesn't close tightly. Some blood from the left ventricle flows backward into the left atrium, instead of forward into the aorta, with each heartbeat. Regurgitation refers to the leakage (backflow) of blood through a heart valve.
Primary mitral regurgitation is due to any disease process that effects the mitral valve apparatus itself. The causes of primary mitral regurgitation include myxomatous degeneration of the mitral valve, ischemic heart disease, coronary artery disease, infective endocarditis, collagen vascular diseases (ie: SLE, Marfan's syndrome), rheumatic heart disease, trauma, balloon valvulotomy of the mitral valve. Myxomatous degeneration of the mitral valve is more common in males, and is more common in advancing age. It is due to a genetic abnormality that results in a defect in the collagen that makes up the mitral valve. This causes a stretching out of the leaflets of the valve and the chordae tendineae. The elongation of the valve leaflets and the chordae tendineae prevent the valve leaflets from fully coapting when the valve is closed, causing the valve leaflets to prolapse into the left atrium, thereby causing mitral regurgitation. Ischemic heart disease causes mitral regurgitation by the combination of ischemic dysfunction of the papillary muscles, and the dilatation of the left ventricle that is present in ischemic heart disease, with the subsequent displacement of the papillary muscles and the dilatation of the mitral valve annulus.
Secondary mitral regurgitation is due to the dilatation of the left ventricle, causing stretching of the mitral valve annulus and displacement of the papillary muscles. This dilatation of the left ventricle can be due to any cause of dilated cardiomyopathy, including aortic insufficiency and nonischemic dilated cardiomyopathy. |
More information on mitral valve diseases (mitral valve prolapse, mitral valve regurgitation, mitral stenosis)
What is mitral valve disease? - There are many diseases which affect the mitral valve and its supporting structures. The most common disorder of the mitral valve is the partial backflow.
What is mitral valve prolapse? - Mitral valve prolapse (MVP) is a heart valve condition marked by the displacement of a thickened mitral valve leaflet into the left atrium during systole.
What causes mitral valve prolapse? - The cause of mitral valve prolapse is unknown. It is more common in people with low body weight and low blood pressure.
What're the symptoms of mitral valve prolapse? - Symptoms of mitral valve prolapse include fatigue, palpitations, chest pain, anxiety, migraine headaches, and even stroke.
How is mitral valve prolapse diagnosed? - Mitral valve prolapse is diagnosed in the course of a physical examination. Echocardiography is useful in diagnosing a prolapsed mitral valve.
What're the treatments for mitral valve prolapse? - Most people with mitral valve prolapse (MVP) do not have symptoms or need treatment. Mitral valve prolapse can be treated with surgical replacement of the mitral valve.
What is mitral valve regurgitation? - Mitral valve regurgitation happens when some of the blood in your heart leaks from the left ventricle into the left atrium.
What causes mitral valve regurgitation? - The causes of primary mitral regurgitation include myxomatous degeneration of the mitral valve, ischemic heart disease, coronary artery disease.
What're the symptoms of mitral regurgitation? - The symptoms associated with mitral regurgitation are dependent on which phase of the disease process the individual is in.
What're the complications of mitral regurgitation? - Complications of mitral regurgitation include congestive heart failure, atrial fibrillation, blood clot, endocarditis.
How is mitral regurgitation diagnosed? - The diagnosis of mitral regurgitation usually employs imaging studies such as echocardiography or magnetic resonance angiography of the heart.
What're the treatments for mitral regurgitation? - The treatment of mitral regurgitation depends on the acuteness of the disease and whether there are associated signs of hemodynamic compromise.
What is mitral valve stenosis? - Mitral valve stenosis is a narrowing of the opening of the mitral valve in the heart. Stenosis of the mitral valve prevents the valve from opening normally.
What causes mitral stenosis? - Mitral stenosis is often caused by having had rheumatic fever. Rheumatic fever can cause an infection in the mitral valve.
What are the symptoms of mitral stenosis? - Symptoms of mitral stenosis include shortness of breath, fainting, dizziness or tiredness, chest pains (angina), chest infections.
How is mitral valve stenosis diagnosed? - Mitral valve stenosis is usually detected by a physician listening to heart sounds. The diagnosis of mitral stenosis is most easily made by echocardiography.
What're the treatments for mitral stenosis? - The treatment options for mitral stenosis include medical management, surgical replacement of the valve, and percutaneous balloon valvuloplasty.
Mitral valve repair and replacement - Mitral valve replacement surgery is open-heart surgery that is done while the patient is under general anesthesia. |
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